Exploring Alternatives in Addiction Therapy: Synthetic Ibogaine Analogs.

The realm of addiction treatment continues to evolve as researchers develop safer and more effective therapeutic options. In recent years, synthetic analogs of ibogaine, a natural compound traditionally used to treat various substance dependencies, have garnered significant attention. These analogs are crafted to retain the beneficial properties of ibogaine without the associated psychoactive and cardiac effects that may pose safety risks.

The Path Forward with Synthetic Ibogaine Analogs

It is well-established that ibogaine can be an effective treatment in interrupting the withdrawal process for narcotics. However, due to the risk of adverse cardiac effects, there is a continued search for safer alternatives. This search has led to the synthesis of analogs like 18-MC (18-Methoxycoronaridine) and TBG (Tabernanthalog). These compounds mirror some of the therapeutic benefits of ibogaine but are engineered to minimize psychoactivity and eliminate the potential for inducing harmful heart rhythms.

18-MC: A Beacon of Hope

18-MC, a derivative of ibogaine, has demonstrated efficacy in animal models for treating dependencies on substances such as alcohol, opiates, and nicotine. Its structural resemblance to ibogaine, devoid of the latter's cardiac liabilities, makes it a promising candidate for human trials in addiction treatment. Moreover, 18-MC has shown potential against leishmaniasis, suggesting a versatility that extends beyond substance use disorders.

The Promise of TBG

Similarly, TBG is gaining scientific interest due to its ability to foster the growth of dendritic structures within the brain. Considering its effectiveness in animal models for mitigating self-administration of drugs of abuse, TBG holds promise in addressing not only addiction but mental health disorders as well by promoting neurogenesis and enhancing neural connectivity.

Ethical Sourcing and Sustainable Practices

The conversation surrounding ibogaine and its analogs extends to sustainability and ethical considerations. The primary natural source of ibogaine, the iboga shrub, is endangered, making it crucial to find alternative and sustainable sources for its production. This has led to the evaluation of other plants such as the Voacanga africana as viable substitutes for ibogaine extraction.

The Curative Relevance of Bwiti House

In the midst of these explorations, there exist traditional approaches to wellness that harness the natural essence of iboga. Bwiti House, renowned for its premier iboga provider training and retreats, champions the authentic practices of the Bwiti Missoko tradition. By honoring the symbiotic relationship between the iboga plant and its cultural heritage, Bwiti House offers a unique pathway to healing, not through the extraction and alteration of iboga's compounds, but through immersive, spiritual engagement with the plant in its natural form.

The Question of Psychedelia in Treatment

A key question remains whether the psychedelic experience provided by natural ibogaine is indispensable for therapeutic effectiveness. Although non-psychoactive analogs offer a solution to health risks, their long-term efficacy and comparative benefits to traditional ibogaine therapy remain subjects for further research. This investigation underscores the potential of utilizing non-psychoactive analogs for patients who may not qualify for or prefer to avoid the psychedelic aspects of treatment.


The therapeutic landscape of ibogaine and its analogs promises a multi-faceted approach to addressing substance dependency and other health conditions. With adherence to responsible and sustainable practices, synthetic ibogaine analogs like 18-MC and TBG could revolutionize the way we perceive, approach, and administer treatments, extending the potential benefits of ibogaine to a broader population. A holistic outlook that considers both pharmacological innovations and traditional practices may ultimately guide the future of integrative addiction therapy.

For further insight and exploration on ibogaine, its traditions, and therapeutic use, Bwiti House offers both knowledge and experience rooted in authenticity and tradition.