How does Iboga work

The Neurochemical Impact of Ibogaine on Brain Health

Ibogaine is a naturally occurring psychoactive substance known for its potential in treating various neurological and psychological conditions. Its effects on the brain are profound, influencing both neurotrophic factors and neurotransmitters, which are crucial for brain health and functionality.

Neurotrophic Factors and Neurotransmitters: A Dual Approach

Ibogaine's mechanism involves an intricate interaction with the brain's neurochemistry. It primarily affects several neurotrophic factors and neurotransmitters, such as Dopamine, N-methyl-d-aspartate (NMDA), kappa-opioid, sigma, and nicotine.
Neurotrophic factors are essential molecules that support the survival, development, and function of neurons. They also promote the growth of new neurons and the formation of synaptic connections. The key neurotrophic factors influenced by Ibogaine include:
- Brain-Derived Neurotrophic Factor (BDNF)
- Glial cell-Derived Neurotrophic Factor (GDNF)
- Nerve Growth Factor (NGF)
- GDNF: A Key Player

The activation of these neurotrophic factors, particularly GDNF, is critical to Ibogaine's long-term anti-addictive effects. GDNF's role is noteworthy, as it not only supports neuron survival and growth but also has been linked to repairing damage caused by long-term drug abuse.

Impact on Neurotransmitters

Ibogaine significantly affects crucial neurotransmitters in the brain, including dopamine and serotonin. It inhibits their transporters, effectively increasing their levels in the brain. This alteration has promising implications for conditions associated with low levels of these neurotransmitters, such as addiction, anxiety, depression, and neurodegenerative diseases like Parkinson’s.

Neurochemical Impacts of Ibogaine

The neurochemical effects of Ibogaine are vast, offering a "Brain Youth Boost" by stimulating the natural release of nor-ibogaine. Here are some highlights of its impact:
- Boosts production of GDNF protein, crucial during early childhood for neuron creation
- Facilitates rapid learning of languages, instruments, and other skills in children, thanks to GDNF
- Stimulates nor-ibogaine release, offering a "Brain Youth Boost"
- Increases GDNF levels significantly post-treatment, mimicking childhood conditions for 3-6 months
- Encourages habit reshaping and environmental reevaluation
- Supports the growth of new habits by enhancing brain flexibility

Ibogaine presents a transformative journey for both the mind and soul, paving the way for significant neurochemical and behavioral changes. Its unique interaction with neurotrophic factors and neurotransmitters underscores its potential as a valuable tool in neurological and psychological therapies.